We’ve put ponies on the moon in KSP before. But what makes this special?
 
This is Realism Overhaul!
 
And I wrote scripts so that the initial launch from Earth, and the lunar lander’s powered descent, were both carried autonomously with no real-time input from me at all.
 
Realism overhaul means instead of a 600 km radius Kerbin (with a ~2,000 m/s orbit velocity) and a 200 km Mun, there’s a 6,370 km Earth (with a 7,800 m/s orbit velocity) and a 1,737 km Moon with an orbital velocity (at 100 km altitude) of about 1,600-1,800 m/s, iirc.
 
Fuel tanks are also lighter, though, so higher mass ratios are easier to achieve, but it ends up cancelling out in such a way that it’s still quite a challenge. Not to mention, the higher ratios mean you have to watch your accelerations more carefully. Starting off with 2 G’s of T/W means that at engine cutoff, you’ll be pulling maybe 20+ G’s. Ponies will die much above 40, or at 20 for too long. Plus there’s craft stress to worry about.
 
To say nothing of ullage, limited ignitions, lack of throttle controls on all but a very few engines built for it, life support requirements, cryogenic fuel boiloff, no reaction wheels (they exist, but work so slowly they’re impractical for larger, crewed craft)… It gets fun :D
 
Here’s an album of the mission.