Lacunae and the Thousand Sons never received any special genetic enhancements similarly to the 1st primarch, however this was due to Lacunae’s alicornhood, to further alter her fragile DNA more would be disastrous, this was proven when Celestia attempted to administer a slight dosage of her RNA into Lacunae, only for the soon-to-be Primarch to collapse in pain as her body was torn apart cell by cell, the Empress managed to purge all trace of her genetic material from Lacunae, but not before her left eye was turned to dust, instead the primarch received all of the necessary modifications magically, using biomancy and powerful biological megaspells to change her into a primarch. As their Primarch’s DNA was spread to the legionaries of the 15th, the genetic instability became apparent as some members started to mutate, change into all sorts of abominations, however the Primarch and her first captain was able to euthanize the mutants before word of this got to the other legions, or worse… The Empress. During the Black Heresy, the Space Wolves and their Primarch: P-21, were deceived by the Warmaster and sent to the planet of Prospero, then a great battle took place as the two legions slaughtered each other, after hours of gathering her arcane strength, her and her entire legion were teleported into the warp, to a planet gifted to them by the Chaos God Sombra. Upon this new planet, the power of the warp, combined with their already strained genetic structure, left hundreds of her marines transforming into chaotic abominations who slaughtered those lucky enough to survive their unstable DNA, to stop this her first captain used ancient zebra magic to cure the surviving marines… The Rubric of Lancer had instead transformed the remainders into naught but dust, sealed within their armor.
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